• Snake Charmer
    An Emerging Explorer in the field.

    Photograph courtesy Zoltan Takacs

    Always Have an Escape Route
    Ive been many times detained, kicked out of countries, barred from entering countries, went on airplanes without tickets, ridden cargo, played hitchhiker. . . Im a pilot. Ive given lifts to other people. You name it. Ive done lots of stuff, but you just want to make sure you are on that side of the line where you always have escape routes.
    Dr. Zoltan Takacs, 2010 Emerging Explorer

    Venom
    There are four major types of venom.

    Cytotoxic venom targets the area around the bite. Cytotoxic venom can lead to necrosis, or the death of tissue around the bite. The venom of Africas puff adder is cytotoxic.

    Hemotoxic venom targets the preys blood and heart. Hemotoxic venom can prevent blood from clotting or induce massive heart attacks. The venom of North Americas eastern diamondback rattlesnake is hemotoxic.

    Neurotoxic venom targets the preys brain and spine. Neurotoxins are usually the most dangerous type of venoms. The venom of Asias coral snakes is neurotoxic.

    Proteolytic venom targets molecular structure. This venom is actually a digestive fluid that begins to break down the preys flesh so the snake can better digest it. Many pit viper species, including South Americas wutu, have proteolytic venom.

    Fangs
    All venomous snakes have fangs. Fangs are long, hollow teeth that deliver venom as the snake bites into a victim. There are three different types of fangs.

    Fixed fangs are permanently fixed in the front of a snakes mouth. Snakes that have fixed fangs are called elapids. Cobras are elapids.

    Folded fangs are longer than fixed fangs, and are hinged so that they fold up into a snakes upper jaw when theyre not being used. Snakes that have folded fangs are called vipers. Rattlesnakes are vipers.

    Colubrid fangs are named after the type of snakes that have them: colubrids. Unlike fixed fangs and folded fangs, colubrid fangs are short and located at the back, not the front, of the snakes mouth. Cat snakes, native to Asia and Australia, are colubrids.

    By Stuart Thornton

    Tuesday, February 1, 2011

    Instead of collecting comic books or sports memorabilia as a kid, Dr. Zoltan Takacs collected all kinds of different snakes.

    The Hungarian herpetologist says his initial interest in snakes came from spending his childhood summers in Transylvania, a region in the neighboring country of Romania. A herpetologist is someone who studies reptiles and amphibians.

    “That’s where I was exposed first to snakes, reptiles, amphibians and other wildlife, so I started to catch them, take them home and keep them in all kinds of basic conditions,” he says. “Later, in high school, this turned into a more advanced snake-keeping hobby. That’s how I got into the snake business.”

    Takacs is currently a research associate and assistant professor at the University of Chicago and a National Geographic Emerging Explorer.

    The herpetologist says he discovered valuable information about snakes during his early encounters with the animals while growing up in Budapest, Hungary. Those experiences were not always pleasant.

    “I kept vipers at home in my room, and I got bitten [once],” he says. “I tried to measure the length of the snake. It was my mistake; just as the other six bites I have had since then. I gave anti-venom to myself . . . just to find out a few weeks later that I’m allergic to the snake anti-venom! I did learn a lot during that early period.”

    Coolest Molecules Nature Ever Invented

    Eventually, Takacs found out that he was not only fascinated by snakes, but that he was also intrigued by their venom, a poisonous fluid some snakes secrete and use on their prey.

    “I think the venom and the molecules in the venom—the toxins—are the coolest molecules nature ever invented,” he says.

    Takacs’ interest in venoms led him to study pharmacology, which is the study of drugs and their effects. Eventually, he earned a PhD from Columbia University in New York City.

    One aspect of venom that intrigued Takacs was how the substance is able to zoom in on particular components of the prey’s body to immobilize or kill it. Some venoms target the way a prey animal’s blood clots. Without the capability to clot, a prey animal quickly bleeds to death. Other venoms target muscles, paralyzing the target. Still other venoms target the heart or lungs, causing the target to suffocate.

    Although these venoms can be deadly to prey animals—and sometimes humans—they can also provide valuable medical assistance for some diseases. Venom that prevents blood from clotting, for instance, may help create a drug for heart attack victims by encouraging blood flow.

    Takacs went on to become one of the inventors of designer toxin technology, a method of uncovering the ways that animal venoms can be used to combat human ailments.

    “Why don’t we use these toxins nature pre-made for us and try to tweak [them] a little bit and come up with a toxin which is exactly doing what we want a drug to do?” he asks.

    Takacs says that he and his fellow scientists have created a toxin library. One area of research could become a drug to combat autoimmune disorders, including rheumatoid arthritis and diabetes.

    “It is like a key and a lock,” he says. “If you have a specific key (the toxin) for a particular lock (the target), then you can cure diseases. We are making the keys from animal venoms, and now we have a key to shut down cells that cause autoimmune disorders.”

    Takacs has traveled to some of the world’s most extreme environments in an attempt to procure his library of animal venoms.

    “So many times, collecting toxins means you just have to go away to a location that is not really disturbed,” he says. “It’s more pristine, because [you’re] more likely to find a species of snake or other animal that you are looking for which hasn’t been studied. Or you meet the local people, who are not really in touch with the mainstream civilization, and they can show you cool stuff like how they can use venom for poisoning their arrows or how they can detect whether a snakebite was from a venomous snake or a non-venomous snake.”

    Dangerous Collection

    It’s no surprise that some of Takacs’ collection missions have turned into life-threatening adventures.

    During a 2008 trip to the Amazon rain forest, a South American rear-fanged snake bit Takacs. “Well, that snake bit me and unfortunately—and not surprisingly—I responded with a very bad allergic reaction to it, and an allergic reaction can kill me,” he says.

    Takacs says his colleagues sped him by boat down the Rio Negro, a tributary of the Amazon River, to the Brazilian city of Manaus. There, he was treated in a hospital. Once he knew he would survive the attack, Takacs wandered through the hospital and took pictures of other patients who had been bitten by snakes.

    Another close call came when Takacs was on a venom-collection mission in an African rain forest back in 2003. “[A] forest elephant in Cameroon was looking eye to eye at me from two to three meters [six to ten feet] away,” he says. “That was a scary moment, because if the elephant decides to come closer . . . than that’s a problem that you can’t fix.”

    Luckily, Takacs had some help as the largest land animal on Earth stared at him from just a few feet away. “My lookout guide—who used to be a poacher but at that time was reformed and was a wildlife officer—he just told me, ‘Zoltan, don’t shake'," Takacs says. “Then he said something in his language, so the elephant turned away and left. At that moment, I had the courage to take a picture, because my camera was on my hand. So I have a close-up picture of the elephant’s [behind].”

    For Takacs, who is also an aircraft pilot and a scuba diver, his pursuit of animal venoms serves as his passport to travel the world.

    “My passion for snakes,” he says, “is part of a larger passion for wildlife and the Earth and exploration.”

  • Term Part of Speech Definition Encyclopedic Entry
    ailment Noun

    illness or disease.

    allergic Adjective

    having a consistent, unusual, negative reaction to a substance.

    amphibian Noun

    an animal able to live both on land and in water.

    anti-venom Noun

    drug or other material that treats the effects of venom. Also called antivenin.

    autoimmune Adjective

    having to do with the response of an organism to its own cells, tissues, and organs.

    civilization Noun

    complex way of life that developed as humans began to develop urban settlements.

    Encyclopedic Entry: civilization
    clot Verb

    to form a clump or semi-solid mass.

    combat Verb

    to fight.

    component Noun

    part.

    designer toxin Noun

    poison manufactured to destroy harmful pests or diseases.

    diabetes Noun

    disease where the body is unable to produce or regulate certain types of carbohydrates.

    disease Noun

    a harmful condition of a body part or organ.

    Emerging Explorer Noun

    an adventurer, scientist, innovator, or storyteller recognized by National Geographic for their visionary work while still early in their careers.

    encounter Verb

    to meet, especially unexpectedly.

    fascinate Verb

    to cause an interest in.

    forest elephant Noun

    species of elephant native to the Congo River rain forest in Africa.

    herpetologist Noun

    person who studies reptiles.

    immobilize Verb

    to prevent any movement or activity.

    initial Adjective

    first.

    intrigue Verb

    to inspire interest or curiosity.

    lung Noun

    organ in an animal that is necessary for breathing.

    medical Adjective

    having to do with the study of medicine or healing.

    memorabilia Noun

    souvenirs, or objects associated with a specific collection or set of memories.

    molecule Noun

    smallest physical unit of a substance, consisting of two or more atoms linked together.

    paralyze Verb

    to prevent movement.

    pharmacology Noun

    science of the creation and effects of drugs.

    PhD Noun

    (doctor of philosophy) highest degree offered by most graduate schools.

    pleasant Adjective

    enjoyable.

    poacher Noun

    person who hunts or fishes illegally.

    poisonous Adjective

    toxic or containing dangerous chemicals.

    prey Noun

    animal that is hunted and eaten by other animals.

    pristine Adjective

    pure or unpolluted.

    procure Verb

    to get, buy, or obtain.

    rain forest Noun

    area of tall evergreen trees and a high amount of rainfall.

    rear-fanged snake Noun

    snake with curved fangs, or hollow teeth for delivering venom, located at the back of its jaw. Also called a colubrid.

    reptile Noun

    animal that breathes air and usually has scales.

    rheumatoid arthritis Noun

    disease of the immune system.

    scuba noun, adjective

    (self-contained underwater breathing apparatus) portable device for breathing underwater.

    secrete Verb

    to discharge a substance.

    snake Noun

    reptile with scales and no limbs.

    suffocate Verb

    to be unable to breathe.

    toxin Noun

    poisonous substance, usually one produced by a living organism.

    Transylvania Noun

    region in central Romania.

    tributary Noun

    stream that feeds, or flows, into a larger stream.

    Encyclopedic Entry: tributary
    venom Noun

    poison fluid made in the bodies of some organisms and secreted for hunting or protection.

    viper Noun

    snake with fixed fangs that secrete venom.

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